ADVAIR HFA
ICSLABA MDI
Fluticasone propionate / Salmeterol · GlaxoSmithKline
Active Medication & Mechanism
- Fluticasone propionate ICS45 mcg, 115 mcg, or 230 mcg per actuation
Synthetic corticosteroid with potent anti-inflammatory activity. Inhibits multiple cell types and mediators involved in airway inflammation.
- Salmeterol xinafoate LABA21 mcg per actuation
Long-acting beta2-adrenergic agonist. Produces prolonged bronchodilation (≥12 hours) via beta2-receptor stimulation on airway smooth muscle.
FDA-Approved Dosing — Strength × Indication
Strength Regimen AsthmaCOPD
45/21 mcg
2 inhalations twice daily (morning and evening, ~12 hours apart) → 180/84 mcg
FDA Approved
For patients not adequately controlled on low-dose ICS or whose disease severity warrants initiation with two maintenance therapies.
Not Approved
Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.
115/21 mcg
2 inhalations twice daily → 460/84 mcg
FDA Approved
For patients not adequately controlled on medium-dose ICS.
Not Approved
Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.
230/21 mcg
2 inhalations twice daily → 920/84 mcg
FDA Approved
For patients not adequately controlled on high-dose ICS.
Not Approved
Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.
All regimens shown apply to adults (≥18 years) unless otherwise noted · verify against current labelling
45/21 mcg 2 inhalations twice daily (morning and evening, ~12 hours apart) → 180/84 mcg
Asthma FDA Approved
For patients not adequately controlled on low-dose ICS or whose disease severity warrants initiation with two maintenance therapies.
COPD Not Approved
Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.
115/21 mcg 2 inhalations twice daily → 460/84 mcg
Asthma FDA Approved
For patients not adequately controlled on medium-dose ICS.
COPD Not Approved
Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.
230/21 mcg 2 inhalations twice daily → 920/84 mcg
Asthma FDA Approved
For patients not adequately controlled on high-dose ICS.
COPD Not Approved
Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.
All regimens shown apply to adults (≥18 years) unless otherwise noted · verify against current labelling
Not a rescue inhaler. Not indicated for acute bronchospasm. Use a SABA (e.g., albuterol).
Related Inhalers
Same active ingredients (Fluticasone/Salmeterol)