ADVAIR HFA

Fluticasone/Salmeterol

ADVAIR HFA

ICSLABA MDI

Fluticasone propionate / Salmeterol · GlaxoSmithKline

Clinical Reference

Active Medication & Mechanism

Fluticasone propionate ICS
45 mcg, 115 mcg, or 230 mcg per actuation

Synthetic corticosteroid with potent anti-inflammatory activity. Inhibits multiple cell types and mediators involved in airway inflammation.
Salmeterol xinafoate LABA
21 mcg per actuation

Long-acting beta2-adrenergic agonist. Produces prolonged bronchodilation (≥12 hours) via beta2-receptor stimulation on airway smooth muscle.

FDA-Approved Dosing by Indication

// approval varies by strength + age

Asthma

3/4 approved regimens

Strength	Population	Dose & Frequency	Total Daily	Status
45/21 mcg	Patients ≥12 years	2 inhalations twice daily (morning and evening, ~12 hours apart) For patients not adequately controlled on low-dose ICS or whose disease severity warrants initiation with two maintenance therapies.	180/84 mcg	FDA Approved
115/21 mcg	Patients ≥12 years	2 inhalations twice daily For patients not adequately controlled on medium-dose ICS.	460/84 mcg	FDA Approved
230/21 mcg	Patients ≥12 years	2 inhalations twice daily For patients not adequately controlled on high-dose ICS.	920/84 mcg	FDA Approved
Any strength	Acute bronchospasm	—	—	Not Approved Not a rescue inhaler. Use a SABA for acute symptoms.

45/21 mcg FDA Approved

Pop · Patients ≥12 years

2 inhalations twice daily (morning and evening, ~12 hours apart)

For patients not adequately controlled on low-dose ICS or whose disease severity warrants initiation with two maintenance therapies.

Total · 180/84 mcg
115/21 mcg FDA Approved

Pop · Patients ≥12 years

2 inhalations twice daily

For patients not adequately controlled on medium-dose ICS.

Total · 460/84 mcg
230/21 mcg FDA Approved

Pop · Patients ≥12 years

2 inhalations twice daily

For patients not adequately controlled on high-dose ICS.

Total · 920/84 mcg
Any strength Not Approved

Pop · Acute bronchospasm

—

Total · — Not a rescue inhaler. Use a SABA for acute symptoms.

COPD

0/1 approved regimens

Strength	Population	Dose & Frequency	Total Daily	Status
Any strength	Adults	—	—	Not Approved Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.

Any strength Not Approved

Pop · Adults

—

Total · — Advair HFA is NOT indicated for COPD. Use Advair Diskus 250/50 for COPD.

Acute Use

0/1 approved regimens

Strength	Population	Dose & Frequency	Total Daily	Status
Any strength	Acute bronchospasm / rescue	—	—	Not Approved Not indicated for acute bronchospasm. Use a SABA (e.g., albuterol).

Any strength Not Approved

Pop · Acute bronchospasm / rescue

—

Total · — Not indicated for acute bronchospasm. Use a SABA (e.g., albuterol).