SEREVENT DISKUS

Salmeterol

SEREVENT DISKUS

LABA DPI

Salmeterol xinafoate · GlaxoSmithKline

Clinical Reference

Active Medication & Mechanism

Salmeterol xinafoate LABA
50 mcg salmeterol per blister

Long-acting beta2-adrenergic agonist. Provides sustained bronchodilation (≥12 hours) via stimulation of beta2-receptors on airway smooth muscle. Onset is approximately 30–48 minutes.

FDA-Approved Dosing by Indication

// approval varies by strength + age

Asthma

1/2 approved regimens

Strength	Population	Dose & Frequency	Total Daily	Status
50 mcg	Patients ≥4 years	1 inhalation twice daily (~12 hours apart) For asthma, should only be used as additional therapy in patients NOT adequately controlled on ICS or whose disease warrants ICS + LABA. MUST be used WITH an ICS.	100 mcg	FDA Approved
Any strength	Acute bronchospasm	—	—	Not Approved Not a rescue inhaler. Onset too slow for acute symptoms. Use a SABA.

50 mcg FDA Approved

Pop · Patients ≥4 years

1 inhalation twice daily (~12 hours apart)

For asthma, should only be used as additional therapy in patients NOT adequately controlled on ICS or whose disease warrants ICS + LABA. MUST be used WITH an ICS.

Total · 100 mcg
Any strength Not Approved

Pop · Acute bronchospasm

—

Total · — Not a rescue inhaler. Onset too slow for acute symptoms. Use a SABA.

COPD

1/1 approved regimens

Strength	Population	Dose & Frequency	Total Daily	Status
50 mcg	Adults (≥18 years)	1 inhalation twice daily (~12 hours apart) Maintenance treatment of bronchospasm associated with COPD, including emphysema and chronic bronchitis.	100 mcg	FDA Approved

50 mcg FDA Approved

Pop · Adults (≥18 years)

1 inhalation twice daily (~12 hours apart)

Maintenance treatment of bronchospasm associated with COPD, including emphysema and chronic bronchitis.

Total · 100 mcg

Exercise-Induced Bronchospasm

1/1 approved regimens

Strength	Population	Dose & Frequency	Total Daily	Status
50 mcg	Patients ≥4 years	1 inhalation at least 30 minutes before exercise Prevention of exercise-induced bronchospasm. Do not use additional doses for 12 hours.	Should not exceed 1 inhalation twice daily	FDA Approved

50 mcg FDA Approved

Pop · Patients ≥4 years

1 inhalation at least 30 minutes before exercise

Prevention of exercise-induced bronchospasm. Do not use additional doses for 12 hours.

Total · Should not exceed 1 inhalation twice daily

Acute Use

0/1 approved regimens

Strength	Population	Dose & Frequency	Total Daily	Status
Any strength	Acute bronchospasm / rescue	—	—	Not Approved Not for acute bronchospasm. Use a SABA.

Any strength Not Approved

Pop · Acute bronchospasm / rescue

—

Total · — Not for acute bronchospasm. Use a SABA.