SPIRIVA RESPIMAT
LAMA SMI
Tiotropium bromide · Boehringer Ingelheim
Active Medication & Mechanism
- Tiotropium bromide monohydrate LAMA1.25 mcg or 2.5 mcg per actuation
Long-acting muscarinic antagonist. Provides 24-hour bronchodilation by blocking M3 muscarinic receptors on airway smooth muscle with very slow receptor dissociation kinetics.
FDA-Approved Dosing by Indication
// approval varies by strength + age Asthma
1/2 approved regimens| Strength | Population | Dose & Frequency | Total Daily | Status |
|---|---|---|---|---|
| 1.25 mcg | Patients ≥6 years | 2 puffs (2.5 mcg total) once daily Add-on maintenance treatment of asthma in patients ≥6 years already on ICS. Not a substitute for ICS. | 2.5 mcg | FDA Approved |
| Any strength | Acute bronchospasm | — | — | Not Approved Not a rescue inhaler. Use a SABA for acute symptoms. |
COPD
1/2 approved regimens| Strength | Population | Dose & Frequency | Total Daily | Status |
|---|---|---|---|---|
| 2.5 mcg | Adults (≥18 years) | 2 puffs (5 mcg total) once daily Long-term, once-daily maintenance treatment of bronchospasm in COPD. Also reduces exacerbations. | 5 mcg | FDA Approved |
| 1.25 mcg | Adults (≥18 years) | — | — | Not Approved The 1.25 mcg strength is NOT indicated for COPD — use the 2.5 mcg strength. |
Acute Use
0/1 approved regimens| Strength | Population | Dose & Frequency | Total Daily | Status |
|---|---|---|---|---|
| Any strength | Acute bronchospasm / rescue | — | — | Not Approved Onset too slow for rescue. Use a SABA. |