SPIRIVA RESPIMAT
LAMA SMI
Tiotropium bromide · Boehringer Ingelheim
Active Medication & Mechanism
- Tiotropium bromide monohydrate LAMA1.25 mcg or 2.5 mcg per actuation
Long-acting muscarinic antagonist. Provides 24-hour bronchodilation by blocking M3 muscarinic receptors on airway smooth muscle with very slow receptor dissociation kinetics.
FDA-Approved Dosing — Strength × Indication
Strength Regimen AsthmaCOPD
1.25 mcg
2 puffs (2.5 mcg total) once daily → 2.5 mcg
FDA Approved
Add-on maintenance treatment of asthma in adults already on ICS. Not a substitute for ICS.
Not Approved
The 1.25 mcg strength is NOT indicated for COPD — use the 2.5 mcg strength.
2.5 mcg
2 puffs (5 mcg total) once daily → 5 mcg
—
FDA Approved
Long-term, once-daily maintenance treatment of bronchospasm in COPD. Also reduces exacerbations.
All regimens shown apply to adults (≥18 years) unless otherwise noted · verify against current labelling
1.25 mcg 2 puffs (2.5 mcg total) once daily → 2.5 mcg
Asthma FDA Approved
Add-on maintenance treatment of asthma in adults already on ICS. Not a substitute for ICS.
COPD Not Approved
The 1.25 mcg strength is NOT indicated for COPD — use the 2.5 mcg strength.
2.5 mcg 2 puffs (5 mcg total) once daily → 5 mcg
Asthma —
COPD FDA Approved
Long-term, once-daily maintenance treatment of bronchospasm in COPD. Also reduces exacerbations.
All regimens shown apply to adults (≥18 years) unless otherwise noted · verify against current labelling
Not a rescue inhaler. Onset too slow for rescue. Use a SABA.
Related Inhalers
Same active ingredients (Tiotropium)