WIXELA INHUB
ICSLABA DPI
Fluticasone propionate / Salmeterol · Viatris (Mylan)
Active Medication & Mechanism
- Fluticasone propionate ICS100 mcg, 250 mcg, or 500 mcg per blister
Synthetic corticosteroid with potent anti-inflammatory activity. Inhibits inflammatory cells and mediators involved in airway inflammation.
- Salmeterol xinafoate LABA50 mcg per blister
Long-acting beta2-adrenergic agonist. Provides prolonged bronchodilation (≥12 hours) via beta2-receptor stimulation.
FDA-Approved Dosing — Strength × Indication
Strength Regimen AsthmaCOPD
100/50 mcg
1 inhalation twice daily (~12 hours apart) → 200/100 mcg
FDA Approved
Generic substitution for Advair Diskus 100/50. For patients not controlled on ICS or whose disease warrants ICS/LABA.
Not Approved
100/50 is NOT indicated for COPD.
250/50 mcg
1 inhalation twice daily → 500/100 mcg
FDA Approved
Generic substitution for Advair Diskus 250/50.
FDA Approved
Maintenance of airflow obstruction in COPD. Only the 250/50 strength is approved for COPD.
500/50 mcg
1 inhalation twice daily → 1000/100 mcg
FDA Approved
Generic substitution for Advair Diskus 500/50.
Not Approved
500/50 is NOT indicated for COPD.
All regimens shown apply to adults (≥18 years) unless otherwise noted · verify against current labelling
100/50 mcg 1 inhalation twice daily (~12 hours apart) → 200/100 mcg
Asthma FDA Approved
Generic substitution for Advair Diskus 100/50. For patients not controlled on ICS or whose disease warrants ICS/LABA.
COPD Not Approved
100/50 is NOT indicated for COPD.
250/50 mcg 1 inhalation twice daily → 500/100 mcg
Asthma FDA Approved
Generic substitution for Advair Diskus 250/50.
COPD FDA Approved
Maintenance of airflow obstruction in COPD. Only the 250/50 strength is approved for COPD.
500/50 mcg 1 inhalation twice daily → 1000/100 mcg
Asthma FDA Approved
Generic substitution for Advair Diskus 500/50.
COPD Not Approved
500/50 is NOT indicated for COPD.
All regimens shown apply to adults (≥18 years) unless otherwise noted · verify against current labelling
Not a rescue inhaler. Not for acute use. Use a SABA.
Related Inhalers
Same active ingredients (Fluticasone/Salmeterol)